Antibiotic therapy and outcome from immune-checkpoint inhibitors

Antibiotic therapy and outcome from immune-checkpoint inhibitors

Blog Article

Abstract Sensitivity to immune checkpoint inhibitor (ICPI) therapy is governed by a complex interplay of tumor and host-related determinants.Epidemiological studies have highlighted that exposure to antibiotic therapy influences the probability of response to ICPI and predict for shorter patient survival across malignancies.Whilst a number of studies have reproducibly documented the detrimental effect of broad-spectrum antibiotics, the Dryer Control Module immune-biologic mechanisms underlying the association with outcome are poorly understood.Perturbation of the gut microbiota, an increasingly well-characterized factor capable of influencing ICPI-mediated immune reconstitution, has been indicated as a putative mechanism to explain the adverse effects attributed to antibiotic exposure in the context Car Model Kit of ICPI therapy.Prospective studies are required to validate antibiotic-mediated gut perturbations as a mechanism of ICPI refractoriness and guide the development of strategies to overcome this barrier to an effective delivery of anti-cancer immunotherapy.